Astrobubble:
Modulating Immune Responses in Space with DNA Origami Nanostructures
Modulating Immune Responses in Space with DNA Origami Nanostructures
Background
As humanity pushes the boundaries of space exploration, one of the most critical health challenges for astronauts is the deterioration of the immune system in space.
We aim to solve this by engineering a DNA origami nanostructure designed to modulate immune responses dynamically.
Introduction
DNA origami is a technique where DNA strands are folded into specific nanoscale shapes. Inspired by pre-existing designs using the Hoberman circle, our therapeutic device is engineered to transition between open and closed states triggered by stimuli such as radiation or chemical signals.
CpG oligonucleotides — short DNA sequences known to influence immune activity – will be attached to the device, and their spacing will change with device transitions.
Objective
The objective is to create a nanodevice that navigates the bloodstream and precisely modulates immune function by manipulating CpG spacing. This DNA origami-based system will present significant advancements in biomedical engineering and increase our knowledge of immune system regulation.
Background
As humanity pushes the boundaries of space exploration, one of the most critical health challenges for astronauts is the deterioration of the immune system in space.
We aim to solve this by engineering a DNA origami nanostructure designed to modulate immune responses dynamically.
Introduction
DNA origami is a technique where DNA strands are folded into specific nanoscale shapes. Inspired by pre-existing designs using the Hoberman circle, our therapeutic device is engineered to transition between open and closed states triggered by stimuli such as radiation or chemical signals.
CpG oligonucleotides — short DNA sequences known to influence immune activity – will be attached to the device, and their spacing will change with device transitions.
Objective
The objective is to create a nanodevice that navigates the bloodstream and precisely modulates immune function by manipulating CpG spacing. This DNA origami-based system will present significant advancements in biomedical engineering and increase our knowledge of immune system regulation.
About Us
Hello, everyone! We are the HubbleBubble team! We are a team of five undergraduates from the University of Sydney, aiming to present our best to BIOMOD 2024.
About Us
Hello, everyone! We are the HubbleBubble team! We are a team of five undergraduates from the University of Sydney, aiming to present our best to BIOMOD 2024.
About Us
Hello, everyone! We are the HubbleBubble team! We are a team of five undergraduates from the University of Sydney, aiming to present our best to BIOMOD 2024.
Concept Video
Concept Video
In this YouTube video, we provide a brief overview of our project, covering its background, concepts, and technical details. We’ve invested countless hours into conceptualizing, designing, and refining our experiments, with multiple iterations along the way. Beyond this video, our site serves as a comprehensive showcase of our projects, reflecting all our ideas and dedication. Feel free to explore and delve into our work. We hope you enjoy your visit and that our passion shines through!:)
In this YouTube video, we provide a brief overview of our project, covering its background, concepts, and technical details. We’ve invested countless hours into conceptualizing, designing, and refining our experiments, with multiple iterations along the way. Beyond this video, our site serves as a comprehensive showcase of our projects, reflecting all our ideas and dedication. Feel free to explore and delve into our work. We hope you enjoy your visit and that our passion shines through!:)